Gene Expression Regulation in Development

Our research focuses on the molecular mechanisms that regulate gene expression. Gene expression is a fundamental process that underlies the functioning of an organism. The process proceeds through a series of consecutive steps at the molecular level: chromatin template preparation, DNA transcription, mRNA maturation and the formation of ribonucleoprotein particles, their intracellular transport, and translation on ribosomes. Each of the steps is controlled by a particular set of regulatory factors, or molecular machines, which are usually multisubunit protein complexes.

We study the mechanisms of gene expression regulation in the context of various processes at the organism level, such as embryogenesis, gametogenesis, immune response, neurogenesis and brain function.

History

Laboratory of Gene Expression Regulation in Development was founded in 2013 for the implementation of contract with Russian Ministry of Education and Science No. 14.B25.31.0022 from June 26, 2013 (with a grant issued to support the scientific research projects under the supervision of the world's leading scientists). The Scientific supervisor of laboratory is Prof. Paul Schedl, Princeton University.

• higher order chromatin structures formation, mechanisms of long-range interaction of genome regulatory elements, and the function of insulators
• molecular events on chromatin template upon genes activation, the mechanisms of enhancer-promoter communication
• structure and functions of transcription protein complexes, chromatin-remodeling complexes
• participation of transcription factors in cell signaling pathways that mediate the immune response
• regulation of biogenesis and local mRNA translation, study of mechanisms of action of CPEB proteins in cell polarity formation
• mechanisms of neurogenesis, long-term memory formation, gametogenesis
• mRNA biogenesis and translation, functions of CPEB family proteins in neurogenesis and gametogenesis
• modelling of cognitive disabilities (Coffin-Siris syndrome) on Drosophila
• molecular genetic analysis and population genetics SNPs, which are significant in the development of cardiometabolic diseases in humans

Publications of laboratory and scientific advisor of lab (jointly with other groups of IGB RAS)

Laboratory conducts joint research with several Laboratories both in Russia and abroad.

• Paul Schedl Laboratory, Princeton University
• Thomas Gregor Laboratory, Princeton University, USA
• John Yates Laboratory, The Scripps Research Institute, USA http://fields.scripps.edu/
• Ennio Giordano Laboratory, Università degli Studi di Napoli "Federico II"
• Filomena Anna Digilio, Institute of research on terrestrial ecosystems (IRET), CNR, Italy
• FAME Laboratory, Centre for Research and Technology Thessaly, Greece
• Laboratory of Immunopathology, Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk, Poland
• Research Center for Genetics and Life Sciences, Sirius University, Sochi
• Laboratory of intracellular signaling, Institute of molecular biology RAS, Moscow
• Laboratory of biochemical genetics of animals, Institute of molecular genetics, Moscow
• Laboratory of neurogenetics, Pavlov Institute of physiology RAS, St-Petersburg
• Research and educational center Photonics and IR Techniques, Bauman Moscow State Technical University, Moscow
• Department of biology and general genetics, Sechenov University, Moscow